Antipyrinum

Antipyrine is known from the poisonous effects it has produced in old-school

practice. Many fatal cases have been recorded, and there can be little doubt that its injudicious

use has determined a fatal issue in many cases that have remained unrecorded. Its action is very

like that of Antifebrin in producing collapse, but it has more effect on the skin, causing scarlet

rash and cedema. A young lady patient of mine who took Antipyrin on her own account,

whenever she thought she might be going to have a headache, developed intense dysmenorrhcea

(to which she was not subject), with depression. This was only removed after she had

discontinued the drug. Later on she took Phenacetin, with the result that an eruption of erythema

appeared on both cheeks, which peeled after a few days, and recurred persistently. It would seem

from the above that the drug is homceopathic to some forms, at least, of neuralgia. One patient

had Cheyne-Stokes respiration. Erythema appears first on face and arms, last on legs. Hansen

mentions its use in enuresis and epistaxis. > Hot drinks.

Fear of becoming insane; nervous anxiety; hallucinations of sight and hearing.

Loss of consciousness.—Fear of impending insanity (mental balance did not return for

some months).—Excitement—Continual crying. —Nervous anxiety.

Throbbing headache; sensation of constriction. Flashes of heat. Headache under ears with earache.

Headache, with toothache; pain behind both ears of tearing character.—Snapping

sensation in head.

Puffiness of lids. Conjunctiva red and oedematous, with lachrymation. Red spots (Apis).

Complete loss of vision.—Eyelids swollen so that eyes were almost closed.—Coryza.

Pains and buzzing. Tinnitus.

Tingling burning in nose, with sneezing and running from eyes and nose; nose and face

swollen.—Coppery smell which comes and goes.

OEdema and puffiness. Red and swollen.

• ▸Swelling of lips.
• ▸Burning of mouth and gums.
• ▸Ulceration of lips and tongue; vesicles and bullae.
• ▸Small lump in cheek.
• ▸Tongue swollen.
• ▸Bloody saliva.
• ▸Toothache along lower jaw.

Tingling burning in gums, mouth, and throat.—Lump in mouth about an inch thick

just below level of upper teeth (passed away in half-hour).

General toothache, together with headache; pain behind both ears of a tearing

character.

Dryness, burning, swelling, |. side of throat with aphonia; |. tonsil white and

swollen.—Tight, constricted feeling.

• ▸Pain on swallowing.
• ▸Expectoration of fetid pus.
• ▸Abscess, white false membrane.
• ▸Sensation of burning.

Nausea and vomiting; burning and pain.

Attacks of excitement accompanied by vomiting (in a child).—Epigastric pain,

causing to bend double and cry out.—Expanding sensation rising from stomach.

Diminished. Penis black.

Itching and burning in vagina. Menses suppressed. Watery leucorrhoea.

• ▸Fluent coryza.
• ▸Nasal mucous membrane swollen.
• ▸Dull pains in frontal sinus.
• ▸Aphonia.
• ▸Oppression and dyspnoea.
• ▸Cheyne-Stokes respiration.

Faintness, with sensation of stoppage of heart. Throbbing throughout the body. Rapid, weak, irregular pulse.

Sensation as though contents of thorax and abdomen were being forcibly drawn up

towards throat, and r. testicle to abdomen.—Dyspncea; tightness of chest—Sensation of tumour

over notch of sternum.—Inability to lie down.

• ▸Cramp in r.
• ▸arm.
• ▸—Fingers of r.
• ▸hand clenched in the form of a claw.

24. Generalities—Feeling of numberless pins pricking him down each side of the neck,

• ▸extending down r.
• ▸chest and abdomen, particularly severe r.
• ▸side of scrotum and r.
• ▸testicle, also

in legs and feet, severely r., slightly 1——Sensation as if contents of chest and abdomen drawn

upwards, felt he was "drawn in a ruck," and, being unable to stand, fell on the floor—Trembled

violently all over, had cramp in r. arm.—Epileptic attacks, with partial unilateral twitching;

contraction of muscles; chattering of teeth; jactitation —Cyanosis.—Collapse.—Throbbing all over

body.—Sensation as if inside of body were filled with ice.

• ▸Erythema, eczema, pemphigus.
• ▸Intense pruritus.
• ▸Urticaria, appearing and disappearing suddenly, with internal coldness.
• ▸Angioneurotic-oedema.
• ▸Dark blotches on skin of penis, sometimes with oedema.

Rash, erythema or urticaria, with troublesome itching; chiefly between

fingers.—Irregular rounded pimples lying close together, in some places confluent, forming

patches, between which skin was normal, giving a marbled appearance, lasted five days, turned

brownish and desquamated slightly.—Eruption thickest on body and extremities, extensor more

covered than flexor surfaces.—Eruption begins on face and arms, last on legs.—Scarlet macular

eruption.

Excessive perspiration.—Throbbing all over body, coldness of hands and feet,

nervous shuddering without chill—Pulse goes up and down with the temperature.

• ▸Dysmenia.
• ▸Enuresis.
• ▸Epilepsy.
• ▸Epistaxis.
• ▸Erythema.
• ▸German measles.
• ▸Headache.

• ▸Heart, paralysis of.
• ▸Mind, deranged.
• ▸Respiration, Cheyne-Stokes.
• ▸Scarlatina.
• ▸Throat, sore.

Toothache. Urticaria.

• ▸Compare: Anilinum (skin).
• ▸Antefeb.
• ▸; Ars.
• ▸; Chloral; Acon.
• ▸(numbness; rapidity of

attack). Antidoted by: Bell. The symptoms are much intensified in persons addicted to coffee in

excess.

Second decimal potency.

• ▸Epileptiform seizures.
• ▸Contractures.
• ▸Trembling and cramps.
• ▸Crawling and numbness.
• ▸General prostration.