Coca has been used for centuries by natives of West South America as an
intoxicant; and also as a remedy for "Veta," the condition induced in persons on coming to live
in high tablelands:—faintness, throbbing heart and head, dysentery, &c. It is like tea and coffee in
arresting tissue-change, and enabling those who take it to undergo unusual fatigues. Like China
it produces ringing in the ears and deafness and also fever. The alkaloid Cocaine 1s the well-
known local anesthetic. A characteristic symptom of Cocaine poisoning is a sensation as if small
foreign bodies were under the skin, generally like grains of sand; or else as of a worm under the
skin. This is undoubtedly the keynote symptom of Coca. It is known as "Magnan's Symptom,"
named after the eminent neurologist who first described it. His description is "a sensation as if
foreign bodies were under the skin, generally small round substances like grains of sand."
Korkasoff reports a case of multiple neuritis in which this symptom was present. The patient was
a woman who was being treated for a uterine affection by means of vaginal tampons containing
Cocaine. A discontinuance of these caused the disappearance of the symptom. Cooper cured a
case of chronic rheumatism in an aged woman who had this symptom, with the fraction of a
- grain of Cocaine given in single doses at long intervals.
- Dr.
- J.
- W.
- Springthorpe described (H.
- W.
- ,
February, 1896) a variety of this symptom experienced by himself, and recorded in a paper
entitled "The Confessions of a Cocainist." He called it "Hunting the Cocaine bug." "You
imagine," he says, "that in your skin are worms, or similar things, moving along. If you touch
them with wool, and especially with absorbent wool, they run away and disappear, only to peep
cautiously out of some corner to see if there is any danger. These worms are projected only on
the Cocainist's own person or clothing. He sees them on his linen, in his skin, creeping along his
penholder, but not on other people or things, and not on clothes brought clean from the laundry."
In a case reported in Lancet, June, 1886, a man who had a 4 per cent. solution of Cocaine applied
to a tooth, swallowed twenty to thirty drops of the solution. Half an hour after, he was seized
with: (/) Feeling of faintness and giddiness; (2) next, an attack of palpitation with a sense of
flushing, especially up the back. There was marked diminution of smell; great difficulty in
producing vomiting; a scarlatina-like rash over the body, especially about the neck; dimness of
vision; relaxation of sphincters and weakness of extremities; the mind remained clear, but the
pulse was fast, weak and intermittent. A striking case was recorded in the British Medical
Journal of December 13, 1890: "At a meeting of the Paris Académie de Médecine on December
2nd, M. Hallopeau presented a communication, in which, after distinguishing two forms of
cocaine poisoning-namely, the acute, in which the symptoms are produced immediately after a
dose and speedily pass off, and the chronic, in which they are due to the prolonged use of the
drug—he related a case which in his opinion showed that the poisonous effects, while coming on
acutely, might last for a considerable time. On March 7, 1890, a man had about eight
milligrammes of hydrochlorate of cocaine injected into his gum as a preliminary to the extraction
of a tooth. Toxic symptoms at once supervened. There was intense precordial oppression, with