Trimethyl., which is prepared from herring-brine among other sources, has a
very unpleasant and penetrating fish-like odour. At one time it was regarded as a panacea in
cases of acute rheumatism. Experiments on patients and others show that it diminishes the
amount of urea excreted. Hansen gives these as characteristics: great pains in wrist-joints, also
great restlessness, pains in ankle-joints from standing < slight movement. C. Carleton Smith (H.
P., vi. 432) gives these: "Rheumatism, when the needle held in the fingers gets so heavy she
cannot sew." "Copious diarrhoea with pains in ankle-joints but not in wrists; thirst for large
quantities of cold water (like Bry.)."